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NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models.
Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Kaliyamoorthy V, Zhang H, Sreenivasmurthy SG, Malampati S, Wang ZY, Zhu Z, Tong BC, Cheung KH, Lu JH, Durairajan SSK, Li M. Iyaswamy A, et al. Among authors: krishnamoorthi sk. J Food Drug Anal. 2020 Jan;28(1):132-146. doi: 10.1016/j.jfda.2019.09.004. Epub 2019 Oct 8. J Food Drug Anal. 2020. PMID: 31883601 Free article.
Targeting Aggrephagy for the Treatment of Alzheimer's Disease.
Malampati S, Song JX, Chun-Kit Tong B, Nalluri A, Yang CB, Wang Z, Gopalkrishnashetty Sreenivasmurthy S, Zhu Z, Liu J, Su C, Krishnamoorthi S, Iyaswamy A, Cheung KH, Lu JH, Li AM. Malampati S, et al. Cells. 2020 Jan 28;9(2):311. doi: 10.3390/cells9020311. Cells. 2020. PMID: 32012902 Free PMC article. Review.
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease.
Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK, Li M. Iyaswamy A, et al. Among authors: krishnamoorthi sk. Front Pharmacol. 2020 Oct 30;11:584770. doi: 10.3389/fphar.2020.584770. eCollection 2020. Front Pharmacol. 2020. PMID: 33192524 Free PMC article. Review.
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Tong BC, Wu AJ, Huang AS, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Zhu Z, Su C, Liu J, Song J, Lu JH, Tan J, Pan W, Li M, Cheung KH. Tong BC, et al. Autophagy. 2022 Mar;18(3):624-642. doi: 10.1080/15548627.2021.1945220. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313551 Free PMC article.
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2.
Yang CB, Liu J, Tong BC, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi S, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH, Li M. Yang CB, et al. Acta Pharmacol Sin. 2022 May;43(5):1251-1263. doi: 10.1038/s41401-021-00711-7. Epub 2021 Aug 20. Acta Pharmacol Sin. 2022. PMID: 34417577 Free PMC article.
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy.
Zhu Z, Liu LF, Su CF, Liu J, Tong BC, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Guan XJ, Kan YX, Xie WJ, Zhao CL, Cheung KH, Lu JH, Tan JQ, Zhang HJ, Song JX, Li M. Zhu Z, et al. Acta Pharmacol Sin. 2022 Oct;43(10):2511-2526. doi: 10.1038/s41401-022-00871-0. Epub 2022 Feb 25. Acta Pharmacol Sin. 2022. PMID: 35217810 Free PMC article.
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