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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E. Blandino-Rosano M, et al. Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014. Nat Commun. 2017. PMID: 28699639 Free PMC article.
Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy.
Israeli T, Riahi Y, Garzon P, Louzada RA, Werneck-de-Castro JP, Blandino-Rosano M, Yeroslaviz-Stolper R, Kadosh L, Tornovsky-Babeay S, Hacker G, Israeli N, Agmon O, Tirosh B, Cerasi E, Bernal-Mizrachi E, Leibowitz G. Israeli T, et al. Among authors: werneck de castro jp. Diabetes. 2022 Mar 1;71(3):453-469. doi: 10.2337/db21-0281. Diabetes. 2022. PMID: 34862201 Free PMC article.
Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling.
Blandino-Rosano M, Scheys JO, Werneck-de-Castro JP, Louzada RA, Almaça J, Leibowitz G, Rüegg MA, Hall MN, Bernal-Mizrachi E. Blandino-Rosano M, et al. Among authors: werneck de castro jp. Am J Physiol Endocrinol Metab. 2022 Aug 1;323(2):E133-E144. doi: 10.1152/ajpendo.00076.2022. Epub 2022 Jun 20. Am J Physiol Endocrinol Metab. 2022. PMID: 35723227 Free PMC article.
Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice.
Blandino-Rosano M, Louzada RA, Werneck-De-Castro JP, Lubaczeuski C, Almaça J, Rüegg MA, Hall MN, Leibowitz G, Bernal-Mizrachi E. Blandino-Rosano M, et al. Among authors: werneck de castro jp. Mol Metab. 2023 Sep;75:101769. doi: 10.1016/j.molmet.2023.101769. Epub 2023 Jul 7. Mol Metab. 2023. PMID: 37423392 Free PMC article.
54 results