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MCART1/SLC25A51 is required for mitochondrial NAD transport.
Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T, Lewis CA, Sabatini DM. Kory N, et al. Among authors: sabatini dm. Sci Adv. 2020 Oct 21;6(43):eabe5310. doi: 10.1126/sciadv.abe5310. Print 2020 Oct. Sci Adv. 2020. PMID: 33087354 Free PMC article.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. Pacold ME, et al. Among authors: sabatini dm. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Nat Chem Biol. 2016. PMID: 27110680 Free PMC article.
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.
Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC. Ilic N, et al. Among authors: sabatini dm. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10. Proc Natl Acad Sci U S A. 2017. PMID: 28396387 Free PMC article.
NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM. Wyant GA, et al. Among authors: sabatini dm. Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26. Science. 2018. PMID: 29700228 Free PMC article.
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz ÖH. Mihaylova MM, et al. Among authors: sabatini dm. Cell Stem Cell. 2018 May 3;22(5):769-778.e4. doi: 10.1016/j.stem.2018.04.001. Cell Stem Cell. 2018. PMID: 29727683 Free PMC article.
Histidine catabolism is a major determinant of methotrexate sensitivity.
Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM. Kanarek N, et al. Among authors: sabatini dm. Nature. 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11. Nature. 2018. PMID: 29995852 Free PMC article.
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.
Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM. Kory N, et al. Among authors: sabatini dm. Science. 2018 Nov 16;362(6416):eaat9528. doi: 10.1126/science.aat9528. Science. 2018. PMID: 30442778 Free PMC article.
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.
Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW. Bayraktar EC, et al. Among authors: sabatini dm. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):303-312. doi: 10.1073/pnas.1816656115. Epub 2018 Dec 12. Proc Natl Acad Sci U S A. 2019. PMID: 30541894 Free PMC article.
287 results