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Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia.
Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Ansarullah, et al. Among authors: plettenburg o. Nature. 2021 Apr;592(7852):E1. doi: 10.1038/s41586-021-03347-z. Nature. 2021. PMID: 33712809 No abstract available.
Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.
Keipert S, Kutschke M, Ost M, Schwarzmayr T, van Schothorst EM, Lamp D, Brachthäuser L, Hamp I, Mazibuko SE, Hartwig S, Lehr S, Graf E, Plettenburg O, Neff F, Tschöp MH, Jastroch M. Keipert S, et al. Among authors: plettenburg o. Cell Metab. 2017 Aug 1;26(2):437-446.e5. doi: 10.1016/j.cmet.2017.07.016. Cell Metab. 2017. PMID: 28768181 Free article.
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC. Kyriakou E, et al. Among authors: plettenburg o. J Med Chem. 2018 Dec 27;61(24):11144-11157. doi: 10.1021/acs.jmedchem.8b01224. Epub 2018 Dec 7. J Med Chem. 2018. PMID: 30525586
Inceptor counteracts insulin signalling in β-cells to control glycaemia.
Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Ansarullah, et al. Among authors: plettenburg o. Nature. 2021 Feb;590(7845):326-331. doi: 10.1038/s41586-021-03225-8. Epub 2021 Jan 27. Nature. 2021. PMID: 33505018
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
Hartleben G, Schorpp K, Kwon Y, Betz B, Tsokanos FF, Dantes Z, Schäfer A, Rothenaigner I, Monroy Kuhn JM, Morigny P, Mehr L, Lin S, Seitz S, Tokarz J, Artati A, Adamsky J, Plettenburg O, Lutter D, Irmler M, Beckers J, Reichert M, Hadian K, Zeigerer A, Herzig S, Berriel Diaz M. Hartleben G, et al. Among authors: plettenburg o. EMBO Mol Med. 2021 Apr 9;13(4):e12461. doi: 10.15252/emmm.202012461. Epub 2021 Mar 5. EMBO Mol Med. 2021. PMID: 33665961 Free PMC article.
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
Gerckens M, Schorpp K, Pelizza F, Wögrath M, Reichau K, Ma H, Dworsky AM, Sengupta A, Stoleriu MG, Heinzelmann K, Merl-Pham J, Irmler M, Alsafadi HN, Trenkenschuh E, Sarnova L, Jirouskova M, Frieß W, Hauck SM, Beckers J, Kneidinger N, Behr J, Hilgendorff A, Hadian K, Lindner M, Königshoff M, Eickelberg O, Gregor M, Plettenburg O, Yildirim AÖ, Burgstaller G. Gerckens M, et al. Among authors: plettenburg o. Sci Adv. 2021 Dec 24;7(52):eabb3673. doi: 10.1126/sciadv.abb3673. Epub 2021 Dec 22. Sci Adv. 2021. PMID: 34936468 Free PMC article.
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Sekar R, Motzler K, Kwon Y, Novikoff A, Jülg J, Najafi B, Wang S, Warnke AL, Seitz S, Hass D, Gancheva S, Kahl S, Yang B, Finan B, Schwarz K, Okun JG, Roden M, Blüher M, Müller TD, Krahmer N, Behrends C, Plettenburg O, Miaczynska M, Herzig S, Zeigerer A. Sekar R, et al. Among authors: plettenburg o. Cell Metab. 2022 Nov 1;34(11):1824-1842.e9. doi: 10.1016/j.cmet.2022.09.022. Epub 2022 Oct 14. Cell Metab. 2022. PMID: 36243006 Free article.
Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM. Dawidowski M, et al. Among authors: plettenburg o. J Med Chem. 2020 Jan 23;63(2):847-879. doi: 10.1021/acs.jmedchem.9b01876. Epub 2020 Jan 6. J Med Chem. 2020. PMID: 31860309
A patent review of MALT1 inhibitors (2013-present).
Hamp I, O'Neill TJ, Plettenburg O, Krappmann D. Hamp I, et al. Among authors: plettenburg o, o neill tj. Expert Opin Ther Pat. 2021 Dec;31(12):1079-1096. doi: 10.1080/13543776.2021.1951703. Epub 2021 Jul 15. Expert Opin Ther Pat. 2021. PMID: 34214002 Review.
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley CA, Janna Olmos JD, Tippler BG, Schorpp K, Rioton S, Fröhlich T, Plettenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G. Napolitano V, et al. Among authors: plettenburg o. Eur J Med Chem. 2022 Dec 5;243:114778. doi: 10.1016/j.ejmech.2022.114778. Epub 2022 Sep 27. Eur J Med Chem. 2022. PMID: 36194937 Free article.
59 results