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Chemical editing of proteoglycan architecture.
Nat Chem Biol. 2022 Jun;18(6):634-642. doi: 10.1038/s41589-022-01023-5. Epub 2022 May 12.
Nat Chem Biol. 2022.
PMID: 35551261
Free PMC article.
Silencing glycosaminoglycan functions in mouse embryonic stem cells with small molecule antagonists.
Chatterjee S, Stephenson TN, Michalak AL, Godula K, Huang ML.
Chatterjee S, et al. Among authors: stephenson tn.
Methods Enzymol. 2019;626:249-270. doi: 10.1016/bs.mie.2019.06.023. Epub 2019 Jul 24.
Methods Enzymol. 2019.
PMID: 31606078
Free PMC article.
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Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.
Geer Wallace MA, Kwon DY, Weitzel DH, Lee CT, Stephenson TN, Chi JT, Mook RA Jr, Dewhirst MW, Hong J, Fitzgerald MC.
Geer Wallace MA, et al. Among authors: stephenson tn.
J Proteome Res. 2016 Aug 5;15(8):2688-96. doi: 10.1021/acs.jproteome.6b00237. Epub 2016 Jul 8.
J Proteome Res. 2016.
PMID: 27322910
Free PMC article.
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Evaluation of Manassantin A Tetrahydrofuran Core Region Analogues and Cooperative Therapeutic Effects with EGFR Inhibition.
Kwak SH, Stephenson TN, Lee HE, Ge Y, Lee H, Min SM, Kim JH, Kwon DY, Lee YM, Hong J.
Kwak SH, et al. Among authors: stephenson tn.
J Med Chem. 2020 Jul 9;63(13):6821-6833. doi: 10.1021/acs.jmedchem.0c00151. Epub 2020 Jun 24.
J Med Chem. 2020.
PMID: 32579356
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Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.
Kwon DY, Lee HE, Weitzel DH, Park K, Lee SH, Lee CT, Stephenson TN, Park H, Fitzgerald MC, Chi JT, Mook RA Jr, Dewhirst MW, Lee YM, Hong J.
Kwon DY, et al. Among authors: stephenson tn.
J Med Chem. 2015 Oct 8;58(19):7659-71. doi: 10.1021/acs.jmedchem.5b01220. Epub 2015 Sep 22.
J Med Chem. 2015.
PMID: 26394152
Free PMC article.
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Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity.
Byun JK, Lee SH, Moon EJ, Park MH, Jang H, Weitzel DH, Kim HH, Basnet N, Kwon DY, Lee CT, Stephenson TN, Jeong JH, Patel BA, Park SJ, Chi JT, Dewhirst MW, Hong J, Lee YM.
Byun JK, et al. Among authors: stephenson tn.
Br J Cancer. 2023 Apr;128(8):1491-1502. doi: 10.1038/s41416-023-02148-7. Epub 2023 Feb 9.
Br J Cancer. 2023.
PMID: 36759727
Free PMC article.
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