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Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.
Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS. Replogle JM, et al. Among authors: weissman js. Cell. 2022 Jul 7;185(14):2559-2575.e28. doi: 10.1016/j.cell.2022.05.013. Epub 2022 Jun 9. Cell. 2022. PMID: 35688146 Free PMC article.
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.
Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. Gilbert LA, et al. Among authors: weissman js. Cell. 2013 Jul 18;154(2):442-51. doi: 10.1016/j.cell.2013.06.044. Epub 2013 Jul 11. Cell. 2013. PMID: 23849981 Free PMC article.
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.
Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Gilbert LA, et al. Among authors: weissman js. Cell. 2014 Oct 23;159(3):647-61. doi: 10.1016/j.cell.2014.09.029. Epub 2014 Oct 9. Cell. 2014. PMID: 25307932 Free PMC article.
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.
Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Zalatan JG, et al. Among authors: weissman js. Cell. 2015 Jan 15;160(1-2):339-50. doi: 10.1016/j.cell.2014.11.052. Epub 2014 Dec 18. Cell. 2015. PMID: 25533786 Free PMC article.
Nucleosomes impede Cas9 access to DNA in vivo and in vitro.
Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS. Horlbeck MA, et al. Among authors: weissman js. Elife. 2016 Mar 17;5:e12677. doi: 10.7554/eLife.12677. Elife. 2016. PMID: 26987018 Free PMC article.
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.
Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA. Peters JM, et al. Among authors: weissman js. Cell. 2016 Jun 2;165(6):1493-1506. doi: 10.1016/j.cell.2016.05.003. Epub 2016 May 26. Cell. 2016. PMID: 27238023 Free PMC article.
543 results