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Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2.
Hagey RJ, Elazar M, Pham EA, Tian S, Ben-Avi L, Bernardin-Souibgui C, Yee MF, Moreira FR, Rabinovitch MV, Meganck RM, Fram B, Beck A, Gibson SA, Lam G, Devera J, Kladwang W, Nguyen K, Xiong A, Schaffert S, Avisar T, Liu P, Rustagi A, Fichtenbaum CJ, Pang PS, Khatri P, Tseng CT, Taubenberger JK, Blish CA, Hurst BL, Sheahan TP, Das R, Glenn JS. Hagey RJ, et al. Among authors: beck a. Nat Med. 2022 Sep;28(9):1944-1955. doi: 10.1038/s41591-022-01908-x. Epub 2022 Aug 18. Nat Med. 2022. PMID: 35982307 Free PMC article.
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.
Meyers JM, Ramanathan M, Shanderson RL, Beck A, Donohue L, Ferguson I, Guo MG, Rao DS, Miao W, Reynolds D, Yang X, Zhao Y, Yang YY, Blish C, Wang Y, Khavari PA. Meyers JM, et al. Among authors: beck a. PLoS Pathog. 2021 Oct 1;17(10):e1009412. doi: 10.1371/journal.ppat.1009412. eCollection 2021 Oct. PLoS Pathog. 2021. PMID: 34597346 Free PMC article.
Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection.
Choi SS, van Unen V, Zhang H, Rustagi A, Alwahabi SA, Santos AJM, Chan JE, Lam B, Solis D, Mah J, Röltgen K, Trope W, Guh-Siesel A, Lin Z, Beck A, Edwards C, Mallajosyula V, Martin BA, Dunn JCY, Shrager J, Baric RA, Pinsky B, Boyd SD, Blish CA, Davis MM, Kuo CJ. Choi SS, et al. Among authors: beck a. Res Sq [Preprint]. 2023 May 5:rs.3.rs-2870695. doi: 10.21203/rs.3.rs-2870695/v1. Res Sq. 2023. PMID: 37205380 Free PMC article. Preprint.
An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.
Westberg M, Su Y, Zou X, Huang P, Rustagi A, Garhyan J, Patel PB, Fernandez D, Wu Y, Hao C, Lo CW, Karim M, Ning L, Beck A, Saenkham-Huntsinger P, Tat V, Drelich A, Peng BH, Einav S, Tseng CK, Blish C, Lin MZ. Westberg M, et al. Among authors: beck a. Sci Transl Med. 2024 Mar 13;16(738):eadi0979. doi: 10.1126/scitranslmed.adi0979. Epub 2024 Mar 13. Sci Transl Med. 2024. PMID: 38478629
Associations of Urine and Plasma Metabolites with Kidney Failure and Death in a CKD Cohort.
Steinbrenner I, Schultheiss UT, Bächle H, Cheng Y, Behning C, Schmid M, Yeo WJ, Yu B, Grams ME, Schlosser P, Stockmann H, Gronwald W, Oefner PJ, Schaeffner E, Eckardt KU, Köttgen A, Sekula P; GCKD Investigators. Steinbrenner I, et al. Am J Kidney Dis. 2024 May 28:S0272-6386(24)00787-X. doi: 10.1053/j.ajkd.2024.03.028. Online ahead of print. Am J Kidney Dis. 2024. PMID: 38815646
Practice Patterns of Antiplatelet and Anticoagulant Therapy After Fenestrated/Branched Endovascular Aortic Repair.
Fan EY, Schanzer A, Beck AW, Eagleton MJ, Farber MA, Gasper WJ, Lee WA, Oderich GS, Parodi FE, Schneider DB, Sweet MP, Timaran CH, Simons JP; US Aortic Research Consortium. Fan EY, et al. Among authors: beck aw. J Vasc Surg. 2024 May 23:S0741-5214(24)01220-5. doi: 10.1016/j.jvs.2024.05.041. Online ahead of print. J Vasc Surg. 2024. PMID: 38796031
Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.
Rael VE, Yano JA, Huizar JP, Slayden LC, Weiss MA, Turcotte EA, Terry JM, Zuo W, Thiffault I, Pastinen T, Farrow EG, Jenkins JL, Becker ML, Wong SC, Stevens AM, Otten C, Allenspach EJ, Bonner DE, Bernstein JA, Wheeler MT, Saxton RA; Undiagnosed Diseases Network; Liu B, Majer O, Barton GM. Rael VE, et al. J Exp Med. 2024 Aug 5;221(8):e20232005. doi: 10.1084/jem.20232005. Epub 2024 May 23. J Exp Med. 2024. PMID: 38780621 Free PMC article.
3,550 results