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Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.
Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. Halbrook CJ, et al. Among authors: krall as. Nat Cancer. 2022 Nov;3(11):1386-1403. doi: 10.1038/s43018-022-00463-1. Epub 2022 Nov 21. Nat Cancer. 2022. PMID: 36411320 Free PMC article.
Cancer: A metabolic metamorphosis.
Krall AS, Christofk HR. Krall AS, et al. Nature. 2013 Apr 4;496(7443):38-40. doi: 10.1038/496038a. Nature. 2013. PMID: 23552939 No abstract available.
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Among authors: krall as. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.
Rethinking glutamine addiction.
Krall AS, Christofk HR. Krall AS, et al. Nat Cell Biol. 2015 Dec;17(12):1515-7. doi: 10.1038/ncb3278. Nat Cell Biol. 2015. PMID: 26612572
Cell cycle: Division enzyme regulates metabolism.
Krall AS, Christofk HR. Krall AS, et al. Nature. 2017 Jun 15;546(7658):357-358. doi: 10.1038/nature22504. Epub 2017 Jun 7. Nature. 2017. PMID: 28607481 No abstract available.
Lactate dehydrogenase activity drives hair follicle stem cell activation.
Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. Flores A, et al. Among authors: krall as. Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14. Nat Cell Biol. 2017. PMID: 28812580 Free PMC article.
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Krall AS, et al. Cell Metab. 2021 May 4;33(5):1013-1026.e6. doi: 10.1016/j.cmet.2021.02.001. Epub 2021 Feb 19. Cell Metab. 2021. PMID: 33609439 Free PMC article.
14 results