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Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis.
Apiz Saab JJ, Dzierozynski LN, Jonker PB, AminiTabrizi R, Shah H, Menjivar RE, Scott AJ, Nwosu ZC, Zhu Z, Chen RN, Oh M, Sheehan C, Wahl DR, Pasca di Magliano M, Lyssiotis CA, Macleod KF, Weber CR, Muir A. Apiz Saab JJ, et al. Among authors: macleod kf. Elife. 2023 May 31;12:e81289. doi: 10.7554/eLife.81289. Elife. 2023. PMID: 37254839 Free PMC article.
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA. Humpton TJ, et al. Among authors: macleod kf. Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. Epub 2019 Jul 1. Cancer Discov. 2019. PMID: 31263025 Free PMC article.
Autophagy and cancer cell metabolism.
Anderson CM, Macleod KF. Anderson CM, et al. Among authors: macleod kf. Int Rev Cell Mol Biol. 2019;347:145-190. doi: 10.1016/bs.ircmb.2019.06.002. Epub 2019 Jul 9. Int Rev Cell Mol Biol. 2019. PMID: 31451213 Free PMC article.
Mitochondrial dysfunction in cancer.
Boland ML, Chourasia AH, Macleod KF. Boland ML, et al. Among authors: macleod kf. Front Oncol. 2013 Dec 2;3:292. doi: 10.3389/fonc.2013.00292. Front Oncol. 2013. PMID: 24350057 Free PMC article. Review.
mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.
Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K. Malone CF, et al. Among authors: macleod kf. Cancer Discov. 2017 Dec;7(12):1450-1463. doi: 10.1158/2159-8290.CD-17-0177. Epub 2017 Sep 29. Cancer Discov. 2017. PMID: 28963352 Free PMC article.
Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. Klionsky DJ, et al. Among authors: macleod kf. EMBO J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863. Epub 2021 Aug 30. EMBO J. 2021. PMID: 34459017 Free PMC article. Review.
61 results