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Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis.
Apiz Saab JJ, Dzierozynski LN, Jonker PB, AminiTabrizi R, Shah H, Menjivar RE, Scott AJ, Nwosu ZC, Zhu Z, Chen RN, Oh M, Sheehan C, Wahl DR, Pasca di Magliano M, Lyssiotis CA, Macleod KF, Weber CR, Muir A. Apiz Saab JJ, et al. Among authors: muir a. Elife. 2023 May 31;12:e81289. doi: 10.7554/eLife.81289. Elife. 2023. PMID: 37254839 Free PMC article.
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG. Abbott KL, et al. Among authors: muir a. Elife. 2024 May 24;13:RP95652. doi: 10.7554/eLife.95652. Elife. 2024. PMID: 38787918 Free PMC article.
Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress.
Muir A, Roelants FM, Timmons G, Leskoske KL, Thorner J. Muir A, et al. Elife. 2015 Aug 14;4:e09336. doi: 10.7554/eLife.09336. Elife. 2015. PMID: 26274562 Free PMC article.
In eukaryotes, exposure to hypertonic conditions activates a MAPK (Hog1 in Saccharomyces cerevisiae and ortholog p38 in human cells). ...However, Fps1 closes upon hyperosmotic shock even in hog1 cells, indicating another mechanism to prevent Fps1-mediated glycerol efflux. …
In eukaryotes, exposure to hypertonic conditions activates a MAPK (Hog1 in Saccharomyces cerevisiae and ortholog p38 in human cells). …
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T. Sayin VI, et al. Among authors: muir a. Elife. 2017 Oct 2;6:e28083. doi: 10.7554/eLife.28083. Elife. 2017. PMID: 28967864 Free PMC article.
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression.
Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. Francescone R, et al. Among authors: muir a. Cancer Discov. 2021 Feb;11(2):446-479. doi: 10.1158/2159-8290.CD-20-0775. Epub 2020 Oct 30. Cancer Discov. 2021. PMID: 33127842 Free PMC article.
1,082 results