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Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.
Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Jasuja R, et al. J Clin Endocrinol Metab. 2005 Feb;90(2):855-63. doi: 10.1210/jc.2004-1577. Epub 2004 Nov 2. J Clin Endocrinol Metab. 2005. PMID: 15522925
A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment.
Storer TW, Woodhouse LJ, Sattler F, Singh AB, Schroeder ET, Beck K, Padero M, Mac P, Yarasheski KE, Geurts P, Willemsen A, Harms MK, Bhasin S. Storer TW, et al. J Clin Endocrinol Metab. 2005 Aug;90(8):4474-82. doi: 10.1210/jc.2005-0275. Epub 2005 May 24. J Clin Endocrinol Metab. 2005. PMID: 15914526 Clinical Trial.
Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors.
Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF, Bhasin S. Singh R, et al. Endocrinology. 2006 Jan;147(1):141-54. doi: 10.1210/en.2004-1649. Epub 2005 Oct 6. Endocrinology. 2006. PMID: 16210377 Free PMC article.