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Increase in visceral fat per se does not induce insulin resistance in the canine model.
Castro AV, Woolcott OO, Iyer MS, Kabir M, Ionut V, Stefanovski D, Kolka CM, Szczepaniak LS, Szczepaniak EW, Asare-Bediako I, Paszkiewicz RL, Broussard JL, Kim SP, Kirkman EL, Rios HC, Mkrtchyan H, Wu Q, Ader M, Bergman RN. Castro AV, et al. Obesity (Silver Spring). 2015 Jan;23(1):105-11. doi: 10.1002/oby.20906. Epub 2014 Oct 16. Obesity (Silver Spring). 2015. PMID: 25322680 Free PMC article.
CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs.
Kim SP, Woolcott OO, Hsu IR, Stefanoski D, Harrison LN, Zheng D, Lottati M, Kolka C, Catalano KJ, Chiu JD, Kabir M, Ionut V, Bergman RN, Richey JM. Kim SP, et al. Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1261-8. doi: 10.1152/ajpendo.00496.2011. Epub 2012 Feb 28. Am J Physiol Endocrinol Metab. 2012. PMID: 22374758 Free PMC article.
CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors.
Kabir M, Iyer MS, Richey JM, Woolcott OO, Asare Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Hsu IR, Catalano KJ, Chiu JD, Ionut V, Bergman RN. Kabir M, et al. Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E747-58. doi: 10.1152/ajpendo.00196.2015. Epub 2015 Aug 25. Am J Physiol Endocrinol Metab. 2015. PMID: 26306598 Free PMC article.