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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
Gastroenterology. 2015 Dec;149(7):1932-1943.e9. doi: 10.1053/j.gastro.2015.07.058. Epub 2015 Aug 7.
Gastroenterology. 2015.
PMID: 26255562
Free PMC article.
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.
Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB.
Nagathihalli NS, et al. Among authors: beesetty y.
Cancer Res. 2014 Apr 1;74(7):2062-72. doi: 10.1158/0008-5472.CAN-13-2329. Epub 2014 Feb 11.
Cancer Res. 2014.
PMID: 24520077
Free PMC article.
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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Abbott JR, Hodges TR, Daniels RN, Patel PA, Kennedy JP, Howes JE, Akan DT, Burns MC, Sai J, Sobolik T, Beesetty Y, Lee T, Rossanese OW, Phan J, Waterson AG, Fesik SW.
Abbott JR, et al. Among authors: beesetty y.
J Med Chem. 2018 Jul 26;61(14):6002-6017. doi: 10.1021/acs.jmedchem.8b00360. Epub 2018 Jul 11.
J Med Chem. 2018.
PMID: 29856609
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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
Sarkar D, Olejniczak ET, Phan J, Coker JA, Sai J, Arnold A, Beesetty Y, Waterson AG, Fesik SW.
Sarkar D, et al. Among authors: beesetty y.
J Med Chem. 2020 Aug 13;63(15):8325-8337. doi: 10.1021/acs.jmedchem.0c00511. Epub 2020 Aug 3.
J Med Chem. 2020.
PMID: 32673492
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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW.
Hodges TR, et al. Among authors: beesetty y.
J Med Chem. 2018 Oct 11;61(19):8875-8894. doi: 10.1021/acs.jmedchem.8b01108. Epub 2018 Sep 28.
J Med Chem. 2018.
PMID: 30205005
Free PMC article.
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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.
Akan DT, Howes JE, Sai J, Arnold AL, Beesetty Y, Phan J, Olejniczak ET, Waterson AG, Fesik SW.
Akan DT, et al. Among authors: beesetty y.
ACS Chem Biol. 2019 Mar 15;14(3):325-331. doi: 10.1021/acschembio.8b00869. Epub 2019 Feb 18.
ACS Chem Biol. 2019.
PMID: 30735352
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Carbon availability triggers fungal nitrogen uptake and transport in arbuscular mycorrhizal symbiosis.
Fellbaum CR, Gachomo EW, Beesetty Y, Choudhari S, Strahan GD, Pfeffer PE, Kiers ET, Bücking H.
Fellbaum CR, et al. Among authors: beesetty y.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2666-71. doi: 10.1073/pnas.1118650109. Epub 2012 Jan 30.
Proc Natl Acad Sci U S A. 2012.
PMID: 22308426
Free PMC article.
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Reciprocal rewards stabilize cooperation in the mycorrhizal symbiosis.
Kiers ET, Duhamel M, Beesetty Y, Mensah JA, Franken O, Verbruggen E, Fellbaum CR, Kowalchuk GA, Hart MM, Bago A, Palmer TM, West SA, Vandenkoornhuyse P, Jansa J, Bücking H.
Kiers ET, et al. Among authors: beesetty y.
Science. 2011 Aug 12;333(6044):880-2. doi: 10.1126/science.1208473.
Science. 2011.
PMID: 21836016
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