Efeyan A - Search Results

1

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. Zoncu R, et al. Among authors: efeyan a. Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056. Science. 2011. PMID: 22053050 Free PMC article.

2

mTOR and cancer: many loops in one pathway.

Efeyan A, Sabatini DM. Efeyan A, et al. Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007. Epub 2009 Nov 27. Curr Opin Cell Biol. 2010. PMID: 19945836 Free PMC article.

3

mTOR: from growth signal integration to cancer, diabetes and ageing.

Zoncu R, Efeyan A, Sabatini DM. Zoncu R, et al. Among authors: efeyan a. Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15. Nat Rev Mol Cell Biol. 2011. PMID: 21157483 Free PMC article. Review.

4

Amino acids and mTORC1: from lysosomes to disease.

Efeyan A, Zoncu R, Sabatini DM. Efeyan A, et al. Trends Mol Med. 2012 Sep;18(9):524-33. doi: 10.1016/j.molmed.2012.05.007. Epub 2012 Jun 28. Trends Mol Med. 2012. PMID: 22749019 Free PMC article. Review.

5

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. Laplante M, et al. Among authors: efeyan a. Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008. Cell Metab. 2012. PMID: 22883231 Free PMC article.

6

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. Efeyan A, et al. Nature. 2013 Jan 31;493(7434):679-83. doi: 10.1038/nature11745. Epub 2012 Dec 23. Nature. 2013. PMID: 23263183 Free PMC article.

7

Nutrients and growth factors in mTORC1 activation.

Efeyan A, Sabatini DM. Efeyan A, et al. Biochem Soc Trans. 2013 Aug;41(4):902-5. doi: 10.1042/BST20130063. Biochem Soc Trans. 2013. PMID: 23863153 Free PMC article.

8

RagA, but not RagB, is essential for embryonic development and adult mice.

Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM. Efeyan A, et al. Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24. Dev Cell. 2014. PMID: 24768164 Free PMC article.

9

Nutrient-sensing mechanisms and pathways.

Efeyan A, Comb WC, Sabatini DM. Efeyan A, et al. Nature. 2015 Jan 15;517(7534):302-10. doi: 10.1038/nature14190. Nature. 2015. PMID: 25592535 Free PMC article. Review.

10

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. Okosun J, et al. Among authors: efeyan a. Nat Genet. 2016 Feb;48(2):183-8. doi: 10.1038/ng.3473. Epub 2015 Dec 21. Nat Genet. 2016. PMID: 26691987 Free PMC article.

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