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An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
Stupple PA, Batchelor DV, Corless M, Dorr PK, Ellis D, Fenwick DR, Galan SR, Jones RM, Mason HJ, Middleton DS, Perros M, Perruccio F, Platts MY, Pryde DC, Rodrigues D, Smith NN, Stephenson PT, Webster R, Westby M, Wood A. Stupple PA, et al. Among authors: ellis d. J Med Chem. 2011 Jan 13;54(1):67-77. doi: 10.1021/jm100978n. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128663
Design and optimization of potent, selective antagonists of Oxytocin.
Brown A, Brown L, Ellis D, Puhalo N, Smith CR, Wallace O, Watson L. Brown A, et al. Among authors: ellis d. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4278-81. doi: 10.1016/j.bmcl.2008.06.098. Epub 2008 Jul 3. Bioorg Med Chem Lett. 2008. PMID: 18639455
The design and discovery of novel amide CCR5 antagonists.
Pryde DC, Corless M, Fenwick DR, Mason HJ, Stammen BC, Stephenson PT, Ellis D, Bachelor D, Gordon D, Barber CG, Wood A, Middleton DS, Blakemore DC, Parsons GC, Eastwood R, Platts MY, Statham K, Paradowski KA, Burt C, Klute W. Pryde DC, et al. Among authors: ellis d. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1084-8. doi: 10.1016/j.bmcl.2009.01.012. Epub 2009 Jan 10. Bioorg Med Chem Lett. 2009. PMID: 19167884
Aryloxypyrazines as highly selective antagonists of Oxytocin.
Brown A, Ellis D, Pearce D, Ralph M, Sciammetta N. Brown A, et al. Among authors: ellis d. Bioorg Med Chem Lett. 2009 May 15;19(10):2634-6. doi: 10.1016/j.bmcl.2009.03.160. Epub 2009 Apr 5. Bioorg Med Chem Lett. 2009. PMID: 19376698
Design and synthesis of pyridazinone-based 5-HT(2C) agonists.
Allerton CM, Andrews MD, Blagg J, Ellis D, Evrard E, Green MP, Liu KK, McMurray G, Ralph M, Sanderson V, Ward R, Watson L. Allerton CM, et al. Among authors: ellis d. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5791-5. doi: 10.1016/j.bmcl.2009.07.136. Epub 2009 Aug 6. Bioorg Med Chem Lett. 2009. PMID: 19716297
1,858 results