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The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition.
Pierre JF, Neuman JC, Brill AL, Brar HK, Thompson MF, Cadena MT, Connors KM, Busch RA, Heneghan AF, Cham CM, Jones EK, Kibbe CR, Davis DB, Groblewski GE, Kudsk KA, Kimple ME. Pierre JF, et al. Among authors: groblewski ge. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G431-42. doi: 10.1152/ajpgi.00072.2015. Epub 2015 Jul 16. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26185331 Free PMC article.
Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation.
Messenger SW, Jones EK, Holthaus CL, Thomas DDH, Cooley MM, Byrne JA, Mareninova OA, Gukovskaya AS, Groblewski GE. Messenger SW, et al. Among authors: groblewski ge. J Biol Chem. 2017 May 12;292(19):7828-7839. doi: 10.1074/jbc.M117.781815. Epub 2017 Feb 27. J Biol Chem. 2017. PMID: 28242757 Free PMC article.
Intravenous or luminal amino acids are insufficient to maintain pancreatic growth and digestive enzyme expression in the absence of intact dietary protein.
Baumler MD, Koopmann MC, Thomas DD, Ney DM, Groblewski GE. Baumler MD, et al. Among authors: groblewski ge. Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G338-47. doi: 10.1152/ajpgi.00165.2010. Epub 2010 Jun 10. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20539007 Free PMC article.
We previously reported that rats receiving total parenteral nutrition (TPN) undergo significant pancreatic atrophy characterized by reduced total protein and digestive enzyme expression due to a lack of intestinal stimulation by nutrients (Baumler MD, Nelson DW, Ney DM, Groble …
We previously reported that rats receiving total parenteral nutrition (TPN) undergo significant pancreatic atrophy characterized by reduced …
Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.
Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ. Lugea A, et al. Among authors: groblewski ge. Am J Pathol. 2017 Dec;187(12):2726-2743. doi: 10.1016/j.ajpath.2017.08.017. Epub 2017 Sep 19. Am J Pathol. 2017. PMID: 28935577 Free PMC article.
66 results