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Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast.
Schierle S, Helmstädter M, Schmidt J, Hartmann M, Horz M, Kaiser A, Weizel L, Heitel P, Proschak A, Hernandez-Olmos V, Proschak E, Merk D. Schierle S, et al. Among authors: kaiser a. ChemMedChem. 2020 Jan 7;15(1):50-67. doi: 10.1002/cmdc.201900576. Epub 2019 Nov 19. ChemMedChem. 2020. PMID: 31670489 Free PMC article.
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).
Merk D, Gabler M, Gomez RC, Flesch D, Hanke T, Kaiser A, Lamers C, Werz O, Schneider G, Schubert-Zsilavecz M. Merk D, et al. Among authors: kaiser a. Bioorg Med Chem. 2014 Apr 15;22(8):2447-60. doi: 10.1016/j.bmc.2014.02.053. Epub 2014 Mar 15. Bioorg Med Chem. 2014. PMID: 24685112
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.
Blöcher R, Lamers C, Wittmann SK, Merk D, Hartmann M, Weizel L, Diehl O, Brüggerhoff A, Boß M, Kaiser A, Schader T, Göbel T, Grundmann M, Angioni C, Heering J, Geisslinger G, Wurglics M, Kostenis E, Brüne B, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E. Blöcher R, et al. Among authors: kaiser a. J Med Chem. 2016 Jan 14;59(1):61-81. doi: 10.1021/acs.jmedchem.5b01239. Epub 2015 Dec 25. J Med Chem. 2016. PMID: 26595749
Nonacidic Farnesoid X Receptor Modulators.
Flesch D, Cheung SY, Schmidt J, Gabler M, Heitel P, Kramer J, Kaiser A, Hartmann M, Lindner M, Lüddens-Dämgen K, Heering J, Lamers C, Lüddens H, Wurglics M, Proschak E, Schubert-Zsilavecz M, Merk D. Flesch D, et al. Among authors: kaiser a. J Med Chem. 2017 Aug 24;60(16):7199-7205. doi: 10.1021/acs.jmedchem.7b00903. Epub 2017 Aug 8. J Med Chem. 2017. PMID: 28749691
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.
Schmidt J, Rotter M, Weiser T, Wittmann S, Weizel L, Kaiser A, Heering J, Goebel T, Angioni C, Wurglics M, Paulke A, Geisslinger G, Kahnt A, Steinhilber D, Proschak E, Merk D. Schmidt J, et al. Among authors: kaiser a. J Med Chem. 2017 Sep 28;60(18):7703-7724. doi: 10.1021/acs.jmedchem.7b00398. Epub 2017 Sep 8. J Med Chem. 2017. PMID: 28845983
Allosteric modulation of the farnesoid X receptor by a small molecule.
Gabler M, Kramer J, Schmidt J, Pollinger J, Weber J, Kaiser A, Löhr F, Proschak E, Schubert-Zsilavecz M, Merk D. Gabler M, et al. Among authors: kaiser a. Sci Rep. 2018 May 1;8(1):6846. doi: 10.1038/s41598-018-25158-5. Sci Rep. 2018. PMID: 29717168 Free PMC article.
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. Schierle S, et al. Among authors: kaiser a. J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878767 Free article.
1,215 results