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Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury.
Muili KA, Ahmad M, Orabi AI, Mahmood SM, Shah AU, Molkentin JD, Husain SZ. Muili KA, et al. Among authors: orabi ai. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G898-905. doi: 10.1152/ajpgi.00545.2011. Epub 2012 Feb 9. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22323127 Free PMC article.
Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.
Muili KA, Wang D, Orabi AI, Sarwar S, Luo Y, Javed TA, Eisses JF, Mahmood SM, Jin S, Singh VP, Ananthanaravanan M, Perides G, Williams JA, Molkentin JD, Husain SZ. Muili KA, et al. Among authors: orabi ai. J Biol Chem. 2013 Jan 4;288(1):570-80. doi: 10.1074/jbc.M112.428896. Epub 2012 Nov 12. J Biol Chem. 2013. PMID: 23148215 Free PMC article.
The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.
Lewarchik CM, Orabi AI, Jin S, Wang D, Muili KA, Shah AU, Eisses JF, Malik A, Bottino R, Jayaraman T, Husain SZ. Lewarchik CM, et al. Among authors: orabi ai. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G574-81. doi: 10.1152/ajpgi.00143.2014. Epub 2014 Jul 10. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 25012845 Free PMC article.
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