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An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
J Med Chem. 2011 Jan 13;54(1):67-77. doi: 10.1021/jm100978n. Epub 2010 Dec 3.
J Med Chem. 2011.
PMID: 21128663
Discovery of a small molecule inhibitor through interference with the gp120-CD4 interaction.
Williams DH, Adam F, Fenwick DR, Fok-Seang J, Gardner I, Hay D, Jaiessh R, Middleton DS, Mowbray CE, Parkinson T, Perros M, Pickford C, Platts M, Randall A, Siddle D, Stephenson PT, Tran TD, Vuong H.
Williams DH, et al.
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5246-9. doi: 10.1016/j.bmcl.2009.06.080. Epub 2009 Jun 25.
Bioorg Med Chem Lett. 2009.
PMID: 19620004
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Design and optimisation of potent gp120-CD4 inhibitors.
Tran TD, Adam FM, Calo F, Fenwick DR, Fok-Seang J, Gardner I, Hay DA, Perros M, Rawal J, Middleton DS, Parkinson T, Pickford C, Platts M, Randall A, Stephenson PT, Vuong H, Williams DH.
Tran TD, et al.
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5250-5. doi: 10.1016/j.bmcl.2009.06.102. Epub 2009 Jul 4.
Bioorg Med Chem Lett. 2009.
PMID: 19632839
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Non-benzimidazole containing inhibitors of respiratory syncytial virus.
Pryde DC, Tran TD, Gardner I, Bright H, Stupple P, Galan S, Alsop L, Watson L, Middleton DS, Dayal S, Platts M, Murray EJ, Parkinson T, Webster R.
Pryde DC, et al.
Bioorg Med Chem Lett. 2013 Feb 1;23(3):827-33. doi: 10.1016/j.bmcl.2012.11.062. Epub 2012 Nov 29.
Bioorg Med Chem Lett. 2013.
PMID: 23265891
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Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
Pryde DC, Cook AS, Burring DJ, Jones LH, Foll S, Platts MY, Sanderson V, Corless M, Stobie A, Middleton DS, Foster L, Barker L, Van Der Graaf P, Stacey P, Kohl C, Coggon S, Beaumont K.
Pryde DC, et al. Among authors: platts my.
Bioorg Med Chem. 2007 Jan 1;15(1):142-59. doi: 10.1016/j.bmc.2006.10.002. Epub 2006 Oct 6.
Bioorg Med Chem. 2007.
PMID: 17070062
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The design and discovery of novel amide CCR5 antagonists.
Pryde DC, Corless M, Fenwick DR, Mason HJ, Stammen BC, Stephenson PT, Ellis D, Bachelor D, Gordon D, Barber CG, Wood A, Middleton DS, Blakemore DC, Parsons GC, Eastwood R, Platts MY, Statham K, Paradowski KA, Burt C, Klute W.
Pryde DC, et al. Among authors: platts my.
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1084-8. doi: 10.1016/j.bmcl.2009.01.012. Epub 2009 Jan 10.
Bioorg Med Chem Lett. 2009.
PMID: 19167884
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Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.
Pryde DC, Maw GN, Planken S, Platts MY, Sanderson V, Corless M, Stobie A, Barber CG, Russell R, Foster L, Barker L, Wayman C, Van Der Graaf P, Stacey P, Morren D, Kohl C, Beaumont K, Coggon S, Tute M.
Pryde DC, et al. Among authors: platts my.
J Med Chem. 2006 Jul 13;49(14):4409-24. doi: 10.1021/jm060133g.
J Med Chem. 2006.
PMID: 16821800
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The discovery of small molecule inhibitors of neutral endopeptidase. Structure-activity studies on functionalized glutaramides.
Maw GN, Stobie A, Planken S, Pryde DC, Sanderson V, Platts MY, Corless M, Stacey P, Wayman C, Van Der Graaf P, Kohl C, Coggon S, Beaumont K.
Maw GN, et al. Among authors: platts my.
Chem Biol Drug Des. 2006 Jan;67(1):74-7. doi: 10.1111/j.1747-0285.2005.00320.x.
Chem Biol Drug Des. 2006.
PMID: 16492151
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