Sabatini DM - Search Results

1

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. Kang SA, et al. Among authors: sabatini dm. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. Science. 2013. PMID: 23888043 Free PMC article.

2

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation.

Peng T, Golub TR, Sabatini DM. Peng T, et al. Among authors: sabatini dm. Mol Cell Biol. 2002 Aug;22(15):5575-84. doi: 10.1128/MCB.22.15.5575-5584.2002. Mol Cell Biol. 2002. PMID: 12101249 Free PMC article.

3

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925 Free article.

4

Raptor and mTOR: subunits of a nutrient-sensitive complex.

Kim DH, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Curr Top Microbiol Immunol. 2004;279:259-70. doi: 10.1007/978-3-642-18930-2_15. Curr Top Microbiol Immunol. 2004. PMID: 14560962 Review.

5

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Curr Biol. 2004 Jul 27;14(14):1296-302. doi: 10.1016/j.cub.2004.06.054. Curr Biol. 2004. PMID: 15268862 Free article.

6

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148. Science. 2005. PMID: 15718470

7

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

Ali SM, Sabatini DM. Ali SM, et al. Among authors: sabatini dm. J Biol Chem. 2005 May 20;280(20):19445-8. doi: 10.1074/jbc.C500125200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15809305 Free article.

8

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM. Frias MA, et al. Among authors: sabatini dm. Curr Biol. 2006 Sep 19;16(18):1865-70. doi: 10.1016/j.cub.2006.08.001. Epub 2006 Aug 17. Curr Biol. 2006. PMID: 16919458 Free article.

9

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.

10

Increased mTORC1 signaling UPRegulates stress.

Reiling JH, Sabatini DM. Reiling JH, et al. Among authors: sabatini dm. Mol Cell. 2008 Mar 14;29(5):533-5. doi: 10.1016/j.molcel.2008.02.011. Mol Cell. 2008. PMID: 18342598 Free article.

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