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The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I. Pollard P, et al. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25. Gastroenterology. 2009. PMID: 19248780
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ. Elbediwy A, et al. Development. 2016 May 15;143(10):1674-87. doi: 10.1242/dev.133728. Epub 2016 Mar 17. Development. 2016. PMID: 26989177 Free PMC article.
YAP drives cutaneous squamous cell carcinoma formation and progression.
Vincent-Mistiaen Z, Elbediwy A, Vanyai H, Cotton J, Stamp G, Nye E, Spencer-Dene B, Thomas GJ, Mao J, Thompson B. Vincent-Mistiaen Z, et al. Among authors: spencer dene b. Elife. 2018 Sep 20;7:e33304. doi: 10.7554/eLife.33304. Elife. 2018. PMID: 30231971 Free PMC article.
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer.
Ruiz EJ, Lan L, Diefenbacher ME, Riising EM, Da Costa C, Chakraborty A, Hoeck JD, Spencer-Dene B, Kelly G, David JP, Nye E, Downward J, Behrens A. Ruiz EJ, et al. Among authors: spencer dene b. JCI Insight. 2021 Jul 8;6(13):e124985. doi: 10.1172/jci.insight.124985. JCI Insight. 2021. PMID: 34236045 Free PMC article.
87 results