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Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.
J Lipid Res. 2022 Dec;63(12):100310. doi: 10.1016/j.jlr.2022.100310. Epub 2022 Nov 9.
J Lipid Res. 2022.
PMID: 36370807
Free PMC article.
Effects of microsomal prostaglandin E synthase-1 inhibition on resistance artery tone in patients with end stage kidney disease.
Steinmetz-Späh J, Arefin S, Larsson K, Jahan J, Mudrovcic N, Wennberg L, Stenvinkel P, Korotkova M, Kublickiene K, Jakobsson PJ.
Steinmetz-Späh J, et al.
Br J Pharmacol. 2022 Apr;179(7):1433-1449. doi: 10.1111/bph.15729. Epub 2022 Feb 12.
Br J Pharmacol. 2022.
PMID: 34766335
Free article.
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Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice.
Zhang Y, Steinmetz-Späh J, Idborg H, Zhu L, Li H, Rao H, Chen Z, Guo Z, Hu L, Xu C, Chen H, Korotkova M, Jakobsson PJ, Wang M.
Zhang Y, et al. Among authors: steinmetz spah j.
Br J Pharmacol. 2023 Aug;180(15):1981-1998. doi: 10.1111/bph.16061. Epub 2023 Mar 10.
Br J Pharmacol. 2023.
PMID: 36788645
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Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro.
Liu J, Peng B, Steinmetz-Späh J, Idborg H, Korotkova M, Jakobsson PJ.
Liu J, et al. Among authors: steinmetz spah j.
Prostaglandins Other Lipid Mediat. 2023 Aug;167:106738. doi: 10.1016/j.prostaglandins.2023.106738. Epub 2023 Apr 23.
Prostaglandins Other Lipid Mediat. 2023.
PMID: 37094780
Free article.
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Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis.
Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A.
Elwakeel E, et al. Among authors: steinmetz spah j.
Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116.
Cancer Res. 2022.
PMID: 35105690
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The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential.
Steinmetz-Späh J, Jakobsson PJ.
Steinmetz-Späh J, et al.
Expert Opin Ther Targets. 2023 Jul-Dec;27(11):1115-1123. doi: 10.1080/14728222.2023.2285785. Epub 2023 Dec 7.
Expert Opin Ther Targets. 2023.
PMID: 38015194
Review.
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High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance.
Zaghmi A, Aybay E, Jiang L, Shang M, Steinmetz-Späh J, Wermeling F, Kogner P, Korotkova M, Östling P, Jakobsson PJ, Seashore-Ludlow B, Larsson K.
Zaghmi A, et al. Among authors: steinmetz spah j.
Mol Oncol. 2024 Feb;18(2):317-335. doi: 10.1002/1878-0261.13502. Epub 2023 Aug 21.
Mol Oncol. 2024.
PMID: 37519014
Free PMC article.
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