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Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.
Yuan Y, Xu P, Jiang Q, Cai X, Wang T, Peng W, Sun J, Zhu C, Zhang C, Yue D, He Z, Yang J, Zeng Y, Du M, Zhang F, Ibrahimi L, Schaul S, Jiang Y, Wang J, Sun J, Wang Q, Liu L, Wang S, Wang L, Zhu X, Gao P, Xi Q, Yin C, Li F, Xu G, Zhang Y, Shu G. Yuan Y, et al. Among authors: zhu c, zhu x. EMBO J. 2020 Apr 1;39(7):e103304. doi: 10.15252/embj.2019103304. Epub 2020 Feb 27. EMBO J. 2020. PMID: 32104923 Free PMC article.
Heparin Increases Food Intake through AgRP Neurons.
Zhu C, Xu P, He Y, Yuan Y, Wang T, Cai X, Yu L, Yang L, Wu J, Wang L, Zhu X, Wang S, Gao P, Xi Q, Zhang Y, Xu Y, Jiang Q, Shu G. Zhu C, et al. Among authors: zhu x. Cell Rep. 2017 Sep 5;20(10):2455-2467. doi: 10.1016/j.celrep.2017.08.049. Cell Rep. 2017. PMID: 28877477 Free PMC article.
α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway.
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, Yu L, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Xu P, Shu G. Cai X, et al. Among authors: zhu c, zhu x. FASEB J. 2018 Jan;32(1):488-499. doi: 10.1096/fj.201700670R. Epub 2017 Sep 22. FASEB J. 2018. PMID: 28939592 Free PMC article.
These findings not only provide a molecular basis for the potential use of exercise-generated metabolite AKG in muscle atrophy treatment, but also identify PHD3 as a potential target for the development of therapies for muscle wasting.-Cai, X., Yuan, Y., Liao, Z., Xing, K., Zh …
These findings not only provide a molecular basis for the potential use of exercise-generated metabolite AKG in muscle atrophy treatment, bu …
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