A comparison of some allele-sharing based linkage analysis methods for detecting complex trait loci

Genet Epidemiol. 1999:17 Suppl 1:S639-42. doi: 10.1002/gepi.13701707104.

Abstract

Using randomly selected sib pairs from a subset of the GAW11 simulated data in Problem 2, we compared the results of some linkage analysis methods based on allele sharing. One method was the Haseman-Elston test for a binary disease outcome (unaffected vs. mild or severe). The other methods, which analyzed the trinary ordered outcome unaffected/mild/severe were the Haseman-Elston test, an extended Haseman-Elston incorporating sib-pair sums, variance components analysis, and regression analysis. Our analysis was done without knowledge of the generating model.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Genetic Linkage*
  • Genetic Testing
  • Humans
  • Models, Genetic
  • Models, Statistical
  • Nuclear Family
  • Quantitative Trait, Heritable*
  • Regression Analysis