Abstract
It is now well established that nerve growth factor (NGF) plays a key role in inflammation-induced hyperalgesia. It was also reported that brain derived neurotrophic factor (BDNF), another member of neurotrophins, contributed to the pain pathway as a neurotransmitter in the CNS. The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model. The fast occurring and long lasting down-regulations suggest that GDNF might contribute to pain pathway in a way different from neurotrophins and might play a role in the maintenance of chronic pain status.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arthritis, Experimental / genetics*
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Arthritis, Experimental / metabolism*
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Brain-Derived Neurotrophic Factor / genetics
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DNA Primers
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Female
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Functional Laterality
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Glial Cell Line-Derived Neurotrophic Factor
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Nerve Growth Factor / genetics
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Nerve Growth Factors*
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Nerve Tissue Proteins / genetics*
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Posterior Horn Cells / metabolism*
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RNA, Messenger / metabolism*
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Rats
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Rats, Wistar
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Reverse Transcriptase Polymerase Chain Reaction
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Time Factors
Substances
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Brain-Derived Neurotrophic Factor
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DNA Primers
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Gdnf protein, rat
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Glial Cell Line-Derived Neurotrophic Factor
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Nerve Growth Factors
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Nerve Tissue Proteins
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RNA, Messenger
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Nerve Growth Factor