Abstract
The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acyclovir / administration & dosage
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Acyclovir / analogs & derivatives*
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Acyclovir / therapeutic use
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Administration, Topical
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Animals
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use*
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Female
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Guanine
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Guinea Pigs
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Herpes Genitalis / drug therapy*
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Herpes Genitalis / pathology
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Herpes Labialis / drug therapy*
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Herpes Labialis / pathology
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Herpesvirus 1, Human / drug effects*
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Herpesvirus 2, Human / drug effects*
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Mice
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Mice, Hairless
Substances
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Antiviral Agents
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penciclovir
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Guanine
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acyclovir monophosphate
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Acyclovir