[Benznidazole in the primary chemoprophylaxis of the reactivation of Chagas' disease in chronic chagasic patients using corticosteroids at immunosuppressive doses: is there sufficient evidence for recommending its use?]

Abstract

There is evidence that trypanosomicide drugs prevent the parasitological reactivation of Chagas' disease in patients under corticosteroid therapy. On the other hand there are few reports of clinical reactivation of this disease associated with the use of these immunosuppressive drugs. Primary chemoprophylaxis with trypanosomicide in this situation should not be recommended before being assessed by a randomized controlled trial.