Abstract
The poxvirus molluscum contagiosum (MC) has a worldwide distribution and its prevalence is on the rise. Here we report that the MCV MC013L protein inhibits glucocorticoid and vitamin D, but not retinoid or estrogen, nuclear receptor transactivation. A direct interaction of MC013L with glucocorticoid and vitamin D receptor is supported by yeast two-hybrid, GST pull-down, and far Western blot analyses. Glucocorticoids act as potent inhibitors of keratinocyte proliferation, while vitamin D and retinoids promote and block terminal differentiation, respectively. Therefore, MC013L may promote efficient virus replication by blocking the differentiation of infected keratinocytes. MC013L may be the first member of a new class of poxvirus proteins that directly modulate nuclear receptor-mediated transcription.
Copyright 2000 Academic Press.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
COS Cells
-
Calcitriol / metabolism
-
Cell Nucleus
-
Gene Expression
-
Genes, Reporter
-
Growth Substances / genetics
-
HSP40 Heat-Shock Proteins
-
Heat-Shock Proteins / genetics
-
Heat-Shock Proteins / metabolism
-
Heat-Shock Proteins / physiology*
-
Humans
-
Molecular Sequence Data
-
Molluscum contagiosum virus / genetics
-
Molluscum contagiosum virus / metabolism
-
Molluscum contagiosum virus / physiology*
-
Receptors, Calcitriol / antagonists & inhibitors
-
Receptors, Calcitriol / genetics
-
Receptors, Estrogen / antagonists & inhibitors
-
Receptors, Estrogen / genetics
-
Receptors, Glucocorticoid / antagonists & inhibitors
-
Receptors, Glucocorticoid / genetics
-
Receptors, Retinoic Acid / metabolism
-
Receptors, Steroid / antagonists & inhibitors*
-
Receptors, Steroid / genetics
-
Sequence Homology, Amino Acid
-
Transcription, Genetic
-
Viral Proteins / genetics
-
Viral Proteins / metabolism
-
Viral Proteins / physiology*
-
Virus Replication / physiology
Substances
-
Growth Substances
-
HSP40 Heat-Shock Proteins
-
Heat-Shock Proteins
-
Receptors, Calcitriol
-
Receptors, Estrogen
-
Receptors, Glucocorticoid
-
Receptors, Retinoic Acid
-
Receptors, Steroid
-
Viral Proteins
-
Calcitriol