Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure

Biochemistry. 2001 Apr 3;40(13):3828-46. doi: 10.1021/bi002645h.

Abstract

Two single cysteine substitution mutants at helix surface sites in T4 lysozyme (D72C and V131C) have been modified with a series of nitroxide methanethiosulfonate reagents to investigate the structural and dynamical origins of their electron paramagnetic resonance spectra. The novel reagents include 4-substituted derivatives of either the pyrroline or pyrrolidine series of nitroxides. The spectral line shapes were analyzed as a function of side chain structure and temperature using a simulation method with a single order parameter and diffusion rates about three orthogonal axes as parameters. Taken together, the results provide strong support for an anisotropic motional model of the side chain, which was previously proposed from qualitative features of the spectra and crystal structures of spin labeled T4 lysozyme. Site-specific differences in apparent order parameter are interpreted in terms of backbone dynamics modes with characteristic correlation times in the nanosecond or faster time scale. The saturated 4-substituted pyrrolidine nitroxides are shown to be a suitable template for novel "functionalized" side chains designed to mimic salient features of the native side chains they replace.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Substitution / genetics
  • Anisotropy
  • Arginine / genetics
  • Aspartic Acid / genetics
  • Bacteriophage T4 / enzymology*
  • Bacteriophage T4 / genetics
  • Cysteine / genetics
  • Electron Spin Resonance Spectroscopy
  • Free Radicals / chemistry
  • Models, Molecular
  • Muramidase / chemistry*
  • Muramidase / genetics*
  • Mutagenesis, Site-Directed
  • Nitrogen Oxides / chemistry
  • Protein Conformation
  • Protein Structure, Secondary / genetics
  • Spin Labels* / chemical synthesis
  • Spin Trapping* / methods
  • Temperature
  • Valine / genetics

Substances

  • Free Radicals
  • Nitrogen Oxides
  • Spin Labels
  • Aspartic Acid
  • Arginine
  • Muramidase
  • nitroxyl
  • Valine
  • Cysteine