Comparative in vitro activity of ABT-773, a novel antibacterial ketolide

Antimicrob Agents Chemother. 2001 Jul;45(7):2163-8. doi: 10.1128/AAC.45.7.2163-2168.2001.

Abstract

The in vitro activities of ABT-773, erythromycin, clarithromycin, and azithromycin were compared. ABT-773 was the most active compound against macrolide-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Enterococcus spp. and multidrug-resistant Streptococcus pneumoniae. It also had good activity against gram-negative and atypical respiratory tract pathogens and Helicobacter pylori.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Azithromycin / pharmacology
  • Clarithromycin / pharmacology
  • Drug Resistance, Multiple
  • Enterococcus / drug effects
  • Erythromycin / analogs & derivatives*
  • Erythromycin / pharmacology*
  • Helicobacter pylori / drug effects
  • Humans
  • Ketolides*
  • Microbial Sensitivity Tests
  • Staphylococcus / drug effects
  • Streptococcus / drug effects
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Ketolides
  • Erythromycin
  • Azithromycin
  • Clarithromycin
  • cethromycin