Abstract
The design and synthesis of a novel series of indole derivatives (9) having dual 5-HT transporter reuptake and 5-HT(1A) antagonist activity are described.
MeSH terms
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Antidepressive Agents, Second-Generation / chemical synthesis*
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Antidepressive Agents, Second-Generation / pharmacology
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Carrier Proteins / drug effects
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Carrier Proteins / metabolism
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Drug Design
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Humans
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Indicators and Reagents
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Jurkat Cells
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Kinetics
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Membrane Glycoproteins / drug effects
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Membrane Glycoproteins / metabolism
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Membrane Transport Proteins*
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Nerve Tissue Proteins*
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Piperidines / chemistry
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Piperidines / pharmacology
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin, 5-HT1
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Selective Serotonin Reuptake Inhibitors / chemical synthesis*
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Selective Serotonin Reuptake Inhibitors / pharmacology
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Serotonin Antagonists / chemical synthesis*
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Serotonin Antagonists / pharmacology
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Serotonin Plasma Membrane Transport Proteins
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Structure-Activity Relationship
Substances
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Antidepressive Agents, Second-Generation
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Carrier Proteins
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Indicators and Reagents
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Piperidines
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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SLC6A4 protein, human
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Serotonin Antagonists
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors
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indalpine