Abstract
A 22-year-old woman was admitted in August 2001 for loss of consciousness due to hypoglycemia. Her serum insulin level during the hypoglycemic episode was high at 121 mU/l (normal range: 5-25 mU/l). She had never received an insulin injection. Insulin antibodies by radioimmunoassay were positive. During hospitalisation, the patient presented clinical and biological features of systemic lupus erythematosus (SLE). Treatment with high-dose corticosteroids and cyclophosphamide resulted in restoration of euglycemia associated with resolution of circulating anti-insulin antibodies and parallel improvement in clinical and laboratory features of SLE.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adrenal Cortex Hormones / administration & dosage
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Autoantibodies / analysis
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Autoimmune Diseases*
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / therapeutic use
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Drug Therapy, Combination
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Female
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Humans
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Hypoglycemia / diagnosis
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Hypoglycemia / etiology
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use
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Insulin / blood
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Insulin / immunology*
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Insulin Antibodies / analysis
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Lupus Erythematosus, Systemic / diagnosis*
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Radioimmunoassay
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Syndrome
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Time Factors
Substances
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Adrenal Cortex Hormones
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Autoantibodies
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Immunosuppressive Agents
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Insulin
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Insulin Antibodies
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Cyclophosphamide