GAF film dosimetry of a tandem positioned beta-emitting intravascular brachytherapy source train

Med Phys. 2003 Jun;30(6):1004-12. doi: 10.1118/1.1573206.

Abstract

Coronary artery brachytherapy may require treatment of lesions longer than a single source length. A treatment option is tandem positioning of the single source. This study presents relative dosimetric measurements of a cardiovascular brachytherapy source and the dosimetric characteristics in the junction region of tandem treatments. Measurements were carried out using a Novoste Beta Cath 90Sr/90Y 40 mm beta source in a plastic water phantom. Radiochromic MD-55-2 film, calibrated using both 6 MV photon and 6 MeV electron beams from a linear accelerator, was used as the dosimeter. Dose distributions around a single source and in the junction region of tandem irradiation were measured. Measurements of the near field dose as close as 1.2 mm from the source are presented. Significant over- or underdoses in the junction region of tandem irradiation were quantified. At a radial distance of 2 mm from the longitudinal axis of the source, the dose value in the middle of the junction region, normalized to the dose at 2 mm midline single source, was about 182% for a 2-seed overlap and 16% for a 2-seed gap, respectively. Dose distributions in the junction region as a function of source overlap and radial distance have fairly high gradients and exhibit characteristic patterns. The fraction of prescription dose was found to have a sigmoidal dependence on overlap size, for radial distances ranging between 1.2 and 3 mm. The parameters of these sigmoids, quantified as functions of radial distance, could be used to provide quick and reasonable over/underdose estimates, given any potential overlap or gap in the junction area, with an uncertainty within 10%.

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Beta Particles
  • Brachytherapy / instrumentation*
  • Brachytherapy / methods*
  • Coronary Restenosis / radiotherapy*
  • Film Dosimetry / instrumentation*
  • Film Dosimetry / methods*
  • Humans
  • Piperazines
  • Radiotherapy Dosage*
  • Radiotherapy Planning, Computer-Assisted / instrumentation*
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Radiotherapy, Computer-Assisted / instrumentation
  • Radiotherapy, Computer-Assisted / methods
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Strontium Radioisotopes
  • Vascular Diseases / radiotherapy
  • Yttrium Radioisotopes

Substances

  • Piperazines
  • Strontium Radioisotopes
  • Yttrium Radioisotopes
  • oxypertine