3,5-Nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages

Dejan D Doković; Vanja M Bulatović; Biljana D Bozić; Milena V Kataranovski; Tomislav M Zrakić; Nada N Kovacević

doi:10.1248/cpb.52.853

3,5-Nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages

Chem Pharm Bull (Tokyo). 2004 Jul;52(7):853-4. doi: 10.1248/cpb.52.853.

Authors

Dejan D Doković¹, Vanja M Bulatović, Biljana D Bozić, Milena V Kataranovski, Tomislav M Zrakić, Nada N Kovacević

Affiliation

¹ Faculty of Chemistry, University of Belgrade, Serbia and Montenegro. dejandj@chem.bg.ac.yu

PMID: 15256707
DOI: 10.1248/cpb.52.853

Abstract

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC(50)=6.7+/-0.8 microM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Alkynes / isolation & purification
Alkynes / pharmacology*
Animals
Apiaceae*
Macrophages, Peritoneal / drug effects*
Macrophages, Peritoneal / metabolism
Male
Nitric Oxide / antagonists & inhibitors*
Nitric Oxide / metabolism
Oils, Volatile / isolation & purification
Oils, Volatile / pharmacology*
Plant Roots
Rats
Rhizome*

Substances

Alkynes
Oils, Volatile
Nitric Oxide