A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1265-7. doi: 10.1248/cpb.52.1265.

Abstract

Six lignans including a new lignan (1), beta-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

MeSH terms

  • Animals
  • Balanophoraceae*
  • Cell Line, Tumor
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Lipopolysaccharides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Molecular Structure
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitric Oxide Synthase / biosynthesis
  • Nitric Oxide Synthase Type II
  • Plant Extracts / chemistry

Substances

  • Lignans
  • Lipopolysaccharides
  • Plant Extracts
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse