AIDS, multicentric Castleman's disease, and plasmablastic leukemia: report of a long-term survival

S Horster; C Jung; C Zietz; C D Cohen; M Siebeck; F D Goebel

doi:10.1007/s15010-004-3148-3

AIDS, multicentric Castleman's disease, and plasmablastic leukemia: report of a long-term survival

Infection. 2004 Oct;32(5):296-8. doi: 10.1007/s15010-004-3148-3.

Authors

S Horster¹, C Jung, C Zietz, C D Cohen, M Siebeck, F D Goebel

Affiliation

¹ Medical Policlinic, Pettenkoferstr. 8a, D-80336 Munich, Germany. sophiahorster@gmx.de

PMID: 15624895
DOI: 10.1007/s15010-004-3148-3

Abstract

Plasmablastic leukemia (PL) as a complication of human herpes virus 8 (HHV8)-associated Castleman's disease is marked by a rapid and fatal outcome. In patients with AIDS, survival of 7 to 14 days after diagnosis has been reported. Prompt splenectomy and chemotherapy might lead to a significant survival benefit. Here we report a case of long-term survival in a patient with AIDS and multicentric Castleman's disease (MCD) complicated by PL.

Publication types

Case Reports

MeSH terms

AIDS-Related Opportunistic Infections / virology
Acquired Immunodeficiency Syndrome / complications*
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Castleman Disease / drug therapy
Castleman Disease / etiology*
Castleman Disease / surgery
Herpesviridae Infections / etiology*
Herpesvirus 8, Human
Humans
Leukemia, Plasma Cell / drug therapy
Leukemia, Plasma Cell / etiology*
Leukemia, Plasma Cell / surgery
Male
Splenectomy