Abstract
Recombinant antigens of Cryptosporidium parvum, Cp900 and Cp40 but not Cp15, stimulated C. parvum-specific proliferative immune responses of mesenteric lymph node cells in C57BL/6J mice infected with different isolates (MD, GCH1, UCP, and IOWA) of C. parvum, indicating that both Cp900 and Cp40 are immunodominant targets of cellular immune responses during C. parvum infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Proliferation*
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Cryptosporidium parvum / genetics
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Cryptosporidium parvum / immunology
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Cryptosporidium parvum / metabolism*
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Lymph Nodes / cytology
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Lymph Nodes / metabolism*
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Mice
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Mice, Inbred C57BL
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Protozoan Proteins / genetics
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Protozoan Proteins / immunology
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Protozoan Proteins / metabolism*
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology
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Recombinant Proteins / metabolism*
Substances
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CP15 protein, Cryptosporidium parvum
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Protozoan Proteins
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Recombinant Proteins