High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir

AIDS. 2005 Oct 14;19(15):1695-7. doi: 10.1097/01.aids.0000186821.30489.16.

Abstract

We evaluated the virological outcome of tenofovir plus didanosine-based regimens in 67 HIV-suppressed patients. After a median follow-up of 26 months (IQR 10.5-40.5), 12 (18%) discontinued the therapy because of virological failure. At virological failure 'de novo' selected mutations were identified in 11 of the 12 failing patients, including the K65R mutation in seven patients. These results argue against the use of tenofovir-didanosine not only in naive patients, but also in previously suppressed patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / therapeutic use
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • Didanosine / therapeutic use*
  • Drug Resistance, Multiple, Viral
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Humans
  • Mutation
  • Organophosphonates / therapeutic use*
  • Tenofovir
  • Treatment Failure

Substances

  • Anti-HIV Agents
  • Organophosphonates
  • Tenofovir
  • Adenine
  • Didanosine