Abstract
An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent antiviral activity against cowpox and vaccinia viruses without cytotoxicity in HFF cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemical synthesis
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Adenosine / chemistry
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Adenosine / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Drug Evaluation, Preclinical
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Microbial Sensitivity Tests
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Molecular Conformation
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Orthopoxvirus / drug effects*
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Structure-Activity Relationship
Substances
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7-deazaneplanocin A
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Antiviral Agents
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Adenosine