Abstract
Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Molecular Structure
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Nucleosides / pharmacology*
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Orthopoxvirus / drug effects*
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Orthopoxvirus / physiology*
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Pyrazolones / chemical synthesis
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Pyrazolones / chemistry*
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Pyrazolones / pharmacology*
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Pyrimidines / chemistry*
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Structure-Activity Relationship
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Virus Replication
Substances
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Antiviral Agents
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Nucleosides
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Pyrazolones
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Pyrimidines
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pyrimidine