Abstract
Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / therapeutic use*
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Humans
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Isoniazid / therapeutic use
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Models, Biological*
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Nonlinear Dynamics
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Pyrazinamide / therapeutic use
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Rifampin / therapeutic use
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Sputum / microbiology
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Streptomycin / therapeutic use
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Thioacetazone / therapeutic use
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Tuberculosis, Pulmonary / drug therapy*
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Tuberculosis, Pulmonary / microbiology*
Substances
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Antitubercular Agents
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Pyrazinamide
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Thioacetazone
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Isoniazid
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Rifampin
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Streptomycin