Metabolic syndrome is a global epidemic problem. The latest studies revealed that metabolic syndrome can be associated with low-grade chronic inflammation which is postulated to play an essential role in the atherosclerotic process. The aim of the study was evaluation of selected acute phase proteins concentration in patients with metabolic syndrome.
Material and methods: 30 patients with metabolic syndrome were recruited to the study. The control group comprised 15 healthy persons. In all subjects assessment of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), alpha1-antichymotrypsin (ACT), ceruloplazmin (Cp), haptoglobin (Hp), alpha2-makroglobulin (alpha2-M), with use of rocket immunoelectroforesis method were performed.
Results: In the group with metabolic syndrome concentration of the studied acute phase proteins significantly exceeded those observed in the control group. Positive correlations between BMI, waist circumference and CRP ACT, AGP, Cp, Hp were found.
Conclusions: Metabolic syndrome is associated with increased inflammatory process. Visceral obesity is an important determinant of low-grade inflammation in metabolic syndrome. Increased inflammatory process observed in patients with metabolic syndrome should be considered as a potential factor in atherosclerotic process.