RNA editing in mitochondrial mRNA of trypanosomatids

Trends Biochem Sci. 1991 Feb;16(2):68-72. doi: 10.1016/0968-0004(91)90027-s.

Abstract

The editing of mRNA coding sequences by the modification, removal or addition of nucleotides has recently been recognized as another form of RNA processing. Studies of the extensive editing of mitochondrial mRNAs in trypanosomatids have revealed the involvement of small guide RNAs (gRNAs) which are encoded by the minicircles of kinetoplast DNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Mitochondria / metabolism*
  • Molecular Sequence Data
  • RNA / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA, Guide, Kinetoplastida
  • RNA, Mitochondrial
  • RNA, Protozoan / metabolism
  • Trypanosomatina / genetics*

Substances

  • RNA, Mitochondrial
  • RNA, Protozoan
  • RNA
  • RNA, Guide, Kinetoplastida