Adiponectin (APM1) is a protein produced in adipose tissue. The aim of this study was an assessment of the plasma APM1 concentration in patients with metabolic syndrome. We also analysed the possible correlation between APM1 and anthropometric and biochemical parameters.
Material and methods: There were 81 patients with metabolic syndrome recruited to the study. Patients were divided into following groups: group 1 - with hypertension, group 2 - with obesity, group 3 - with hypertension and obesity, group 4 - with hypertension, obesity and diabetes mellitus type 2. There was a control group consisting of 10 healthy volunteers. We assessed the range of insulin sensitivity using euglicemic metabolic clamp (Ferrannini/de Fronzo) and plasma APM1 concentration (RIA). In every patient the anthropometric and blood pressure measurements were done. Blood samples were taken to assess lipid profile and insulin concentration.
Results: In group 1 and group 2 APM1 was statistically lower than in control group. In group 3 the APM1 concentration was the lowest. In a given group there was a correlation between APM1 and anthropometric parameters (BMI), lipid parameters (TAG, HDL) and blood pressure. The most visible correlation between APM1 and insulin sensitivity (M value in the clamp) was found in the group with hypertension and obesity.
Conclusions: Hypertension is connected with lower APM1. Obesity and diabetes mellitus type 2 coexisting with hypertension lead to the farther lowering of APM1. Obesity is the strongest factor influencing APM1 concentration. The correlation between APM1 and M value emphasises the role of APM1 in pathogenesis of insulin resistance.