Taking vesicular transport to the cilium

Cell. 2007 Jun 15;129(6):1041-3. doi: 10.1016/j.cell.2007.05.049.

Abstract

Defects in protein trafficking within the cell body and cilia are thought to underlie the human disease Bardet-Biedl syndrome (BBS). In this issue, Nachury et al. (2007) reveal that a large complex of proteins implicated in BBS cooperates with Rabin8-the GTP exchange factor for the small GTPase Rab8-to promote cilia formation and presumably movement of membrane proteins from the cell into the cilium.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Bardet-Biedl Syndrome / metabolism*
  • Biological Transport*
  • Cilia / metabolism*
  • Flagella
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Microtubules / metabolism
  • Models, Biological
  • Protein Binding
  • Protein Transport
  • rab GTP-Binding Proteins / metabolism

Substances

  • GTP Phosphohydrolases
  • RAB8A protein, human
  • rab GTP-Binding Proteins