Abstract
Patients with Smith-Magenis syndrome have a high incidence of congenital heart disease that requires open-heart surgery. These patients may have gene deletions that affect cholesterol homeostasis, although no previous association has been made with premature atherosclerosis. Herein, we report a case of such a patient, who experienced a stroke after cardiac surgery because of what we believe to be premature intracerebral atherosclerosis.
MeSH terms
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Abnormalities, Multiple / genetics*
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Adult
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Cardiac Surgical Procedures / adverse effects*
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Female
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Heart Defects, Congenital / genetics
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Heart Defects, Congenital / surgery*
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Humans
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Intracranial Arteriosclerosis / complications*
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Intracranial Arteriosclerosis / diagnosis
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Intracranial Arteriosclerosis / genetics
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Magnetic Resonance Angiography
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Magnetic Resonance Imaging
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Reoperation
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Risk Factors
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Stroke / etiology*
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Stroke / genetics
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Stroke / pathology
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Syndrome
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Treatment Outcome