Use of natural products in anticytokine therapy

T V Gorchakova; I V Suprun; I A Sobenin; A N Orekhov

doi:10.1007/s10517-007-0099-6

Use of natural products in anticytokine therapy

Bull Exp Biol Med. 2007 Mar;143(3):316-9. doi: 10.1007/s10517-007-0099-6.

Authors

T V Gorchakova¹, I V Suprun, I A Sobenin, A N Orekhov

Affiliation

¹ Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences. t-gorchakova@mail.ru

PMID: 18225751
DOI: 10.1007/s10517-007-0099-6

Abstract

This work was designed to study direct anticytokine activity of natural products on the cell model of inflammation. We developed a combination of medicinal plants (calendula, elder, and pansy) with maximum antiinflammatory activity. This combination can be used for pathogenetic therapy of various inflammatory diseases, including atherosclerosis.

MeSH terms

Atherosclerosis / drug therapy
Cells, Cultured
Cytokines / antagonists & inhibitors*
Humans
Inflammation / drug therapy
Inflammation Mediators / antagonists & inhibitors
Inflammation Mediators / blood
Inflammation Mediators / metabolism
Interleukin-1 / antagonists & inhibitors
Interleukin-1 / blood
Interleukin-1 / metabolism
Monocytes / drug effects
Monocytes / immunology
Phytotherapy
Plant Extracts / pharmacology*
Plants, Medicinal
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Tumor Necrosis Factor-alpha / blood
Tumor Necrosis Factor-alpha / metabolism

Substances

Cytokines
Inflammation Mediators
Interleukin-1
Plant Extracts
Tumor Necrosis Factor-alpha