Abstract
Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient's blood was infected by a mixture of T. cruzi I and T. cruzi IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal T. cruzi I population. Our findings do not corroborate the original assumption of innocuity for T. cruzi I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / parasitology*
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Acquired Immunodeficiency Syndrome / complications*
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Adult
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Animals
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Bolivia
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Central Nervous System / parasitology
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Central Nervous System Protozoal Infections / diagnosis
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Central Nervous System Protozoal Infections / etiology
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Central Nervous System Protozoal Infections / parasitology*
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Chagas Disease / etiology*
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Chagas Disease / parasitology
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DNA, Protozoan / blood
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DNA, Protozoan / cerebrospinal fluid
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Electron Transport Complex IV / genetics
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Fatal Outcome
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Humans
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Male
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Microsatellite Repeats / genetics
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Polymorphism, Genetic
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Polymorphism, Restriction Fragment Length
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Recurrence
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Tropism / genetics
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Trypanosoma cruzi / genetics
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Trypanosoma cruzi / isolation & purification
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Trypanosoma cruzi / physiology*
Substances
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DNA, Protozoan
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Electron Transport Complex IV