Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots

Clin Infect Dis. 2009 Apr 15;48(8):1104-6. doi: 10.1086/597464.

Abstract

Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chagas Disease / diagnosis*
  • Chagas Disease / epidemiology*
  • Chagas Disease / transmission
  • Cluster Analysis
  • Computer Simulation
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique
  • Humans
  • Models, Biological
  • Monte Carlo Method
  • Peru / epidemiology
  • Radioimmunoprecipitation Assay
  • Time Factors
  • Topography, Medical
  • Trypanosoma cruzi / isolation & purification*