Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

Cláudio R F Marinho; Luis N Nuñez-Apaza; Karina R Bortoluci; André L Bombeiro; Daniella Z Bucci; Marcos G Grisotto; Luiz R Sardinha; Christian E Jorquera; Sergio Lira; Maria Regina D'Império Lima; José M Alvarez

doi:10.1016/j.micinf.2009.07.011

Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

Microbes Infect. 2009 Nov;11(13):1037-45. doi: 10.1016/j.micinf.2009.07.011. Epub 2009 Aug 4.

Authors

Cláudio R F Marinho¹, Luis N Nuñez-Apaza, Karina R Bortoluci, André L Bombeiro, Daniella Z Bucci, Marcos G Grisotto, Luiz R Sardinha, Christian E Jorquera, Sergio Lira, Maria Regina D'Império Lima, José M Alvarez

Affiliation

¹ Department of Immunology, Biomedical Sciences Institute, University of São Paulo, Av. Professor Lineu Prestes, 1730, São Paulo, SP, CEP-05508-000, Brazil.

PMID: 19660570
DOI: 10.1016/j.micinf.2009.07.011

Abstract

The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chagas Disease / immunology
Chagas Disease / parasitology*
Chronic Disease
Disease Models, Animal
Host-Parasite Interactions
Mice
Parasitemia / immunology
Parasitemia / parasitology
Trypanosoma cruzi / pathogenicity
Trypanosoma cruzi / physiology*